Research Scientist, Cell Therapy Computational Immunologist
Johnson & Johnson
Spring House PA USA

Job Details

Updated on 2021-07-30 08:47:54

Job Description

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is committed to building upon its clinical success with autologous, CAR-directed cellular therapies.  Discovery research efforts in the immuno-oncology, cellular therapy research team are now focused on bringing best-in-class cellular therapies to more patients in need.  Our goal is to incorporate the latest advancements in genetic engineering, allogeneic biology, iPSC technology and optimized chimeric antigen receptor designs to deliver off-the-shelf therapies for treatment in challenging cancer indications.  To accomplish this goal, we are seeking passionate scientists to both enhance our knowledge of the science and apply learnings to further optimize CAR-directed cellular therapy efficacy with the intent to enable more patients to achieve durable, lasting responses.  The cell therapy research team is committed not only to the science but also to personal and professional development for all the members that join the team. 


We are seeking a highly motivated scientist to join us in our mission to make universal, off-the-shelf cell therapy products a reality for cancer patients.  The successful candidate will have both a strong immunology background and experience with next generation sequencing (NGS) pipelines and analyses.  In this hybrid role, the individual will be responsible for establishing relationships between ‘omics data sets and CAR-directed cell therapy functionality to inform our efforts around optimizing the efficacy of drug product candidates.  You will be expected to communicate complex informatics principles, methods, analyses and results to scientists from diverse backgrounds. Success in this position will require a positive, can-do attitude, the ability to work well within a cross-functional team, and the ability to design and execute in vitro assays to study human T cell and NK cell biology.

  • PhD degree is highly preferred, but consideration will be made for candidates with an MS and extensive relevant experience. 
  • Strong foundation in immunology is required, experience working with effector NK or T cells preferred
  • Experience with computational and bioinformatic techniques for analyzing transcriptomic data sets and an interest in utilizing novel methods to integrate functional data sets
  • Experience in a programming language (such as R, Python or Perl) for complex data analysis and a solid background using standard statistical methods
  • Prior experience with gene expression analysis of single cell RNA seq such as 10X genomics or similar technology is required.
  • Expertise in Computational Biology including processing and pathway analysis of gene expression data (i.e. NGS data, RNA seq, ATAC seq or equivalent) is required
  • Ability to design, perform and interpret complex CAR-directed cell therapy in vitro, ex vivo and in vivo experiments is strongly preferred 
  • Self-starter with the ability to work independently and manage multiple experiments simultaneously
  • Ability to contribute to various projects outside of his/her own, and collaborate with stakeholders from all relevant functions is preferred
  • Ability to keep up-to-date with the literature related to his/her field
  • Demonstrate clear and professional verbal and written communication


Johnson & Johnson Family of Companies are equal opportunity employers, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by law.


Primary Location
United States-Pennsylvania-Spring House-Welsh & McKean Roads
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID
Research Scientist, Cell Therapy Computational Immunologist
Johnson & Johnson
Spring House PA USA